LOUIS IGNARRO, PH.D

SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

The following table sets forth certain information with respect to the beneficial ownership of our Common Stock as of July 26, 2021 for: (i) each of our directors; (ii) each of our executive officers; (iii) all of our directors and executive officers as a group; and (iv) all persons, to our knowledge, that are the beneficial owners of more than five percent (5%) of the outstanding shares of Common Stock.

Beneficial ownership is determined in accordance with the rules of the SEC, and includes voting or investment power with respect to the securities. Shares of Common Stock subject to warrants or options that are presently exercisable, or exercisable within 60 days of July 26, 2021, which are indicated by footnote, are deemed outstanding in computing the percentage ownership of the person holding the options, but not in computing the percentage ownership of any other person. Except as otherwise indicated, the holders listed below have sole voting and investment power with respect to all shares of Common Stock shown, subject to applicable community property laws.

Percentage ownership is based on 38,780,038 shares of Common Stock outstanding on July 26, 2021. An asterisk (*) represents beneficial ownership of less than 1%.